SUGGESTED USE
Adults take 2 capsules daily post dinner, with a glass of water.
Product Information
Unived COLOX™ is a plant-based vegan supplement that brings together the powerful synergistic ingredients: Boswellia serrate and BCM-95® Curcumin. Both possess effective anti-inflammatory properties. They effectively prevent muscle damage, cartilage degradation; joint pain, and inflammation while at the same time enabling the overall health of joints thus inducing improved movement, and flexibility and helping the body cope with intense training and exercise-induced stress and inflammation. Also included is plant-based vitamin D3 (Vitashine) in its most bio-available form which is involved in strengthening the cartilage.
Joint pain management needs an integrative approach due to the complex anatomy involved in it. That is why Unived’s COLOX™ is integral to achieving and regaining joint health. Its synergistic action makes it a better and safe formulation for joint health.
COLOX™ can be taken by people who train hard for long hours and are experiencing performance-inhibiting pain and inflammation. It can also be consumed daily as a preventive, to combat various internal breakdowns caused by daily stress (training). Whether you’re a runner, cyclist, triathlete, or hybrid athlete, you can use COLOX™ during your training periods and after competitions/races, to combat inflammation and pain & aid recovery.
Key Benefits
- Blocks COX-2 & 5-LOX pathways, thereby addressing pain, inflammation, and edema.
- Helps reduce exercise-induced inflammation.
- Helps strengthen muscles, and cartilage, and repairs connective tissues.
- Helps your joints cope with the stress they undergo during intensive physical activity.
- Helps with joint and muscular pain and is especially helpful during the recovery & rehab process post-injury.
Ingredient Information
- Boswellia serrata Extract – 480mg
- BCM-95® (Curcugreen®) – 480mg
- Vitashine™ as Cholecalciferol from Lichen – 400 I.U.
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DOMS
Delayed onset muscle soreness (DOMS) is a familiar experience for elite and novice athletes. Symptoms can range from muscle tenderness to severely debilitating pain. DOMS is most prevalent at the beginning of the sporting season when athletes are returning to training following a period of reduced activity. DOMS is also common when athletes are first introduced to certain types of activities regardless of the time of the year. DOMS can affect athletic performance by causing a reduction in joint range of motion, shock attenuation, and peak torque. Alterations in muscle sequencing and recruitment patterns may also occur, causing unaccustomed stress to be placed on muscle ligaments and tendons. These compensatory mechanisms may increase the risk of further injury if a premature return to sport is attempted [1].
Injuries
Foot and ankle injuries are extremely common among athletes and other physically active individuals. Sprains, fractures, and bursitis are other joint-related troubles typically faced by athletes. Prolonged exposure to physical stressors, such as endurance-, strength-, sports training, and occupational tasks can lead to suppression of immune functions and skeletal muscle damage that triggers the inflammatory response. A Swedish study indicates that elite male athletes who participate in high-contact sports such as football, soccer, and rugby have a higher risk of developing knee and hip osteoarthritis than men who exercise little or not at all [2], [3], [4].
Overreaching
Failure of the immune system to properly regulate these responses, as a consequence of excessive training load or sub-optimal recovery, may suppress immune functions, compromise athletic performance and increase the risks of respiratory infections. This phenomenon is known as overreaching when the effects are more transient, lasting days or weeks, and can progress to an over-trained state when the malaise lasts for months [5].
References:
1. Cheung, Karoline, Patria A. Hume, and Linda Maxwell. "Delayed onset muscle soreness." Sports medicine 33.2 (2003): 145-164.
2. Dr. Sheldon Martin, ‘Athletes and Joint Pain: Is it Something you have to live with?, April 2013, Orthoarizona, www.orthopedicarizona.com.
3. Linda Thrasybule, ‘Elite Athletes at a Greater Risk of Arthritis,’ Reuters (Health), NY, 16 Dec 2011, www.reuters.com
4. Goh, Jorming, Chin Leong Lim, and Katsuhiko Suzuki. "Effects of endurance-, strength-, and concurrent training on cytokines and inflammation." Concurrent aerobic and strength training. Springer, Cham, 2019. 125-138.
5. Blain, Emma J., Ahmed Y. Ali, and Victor C. Duance. "Boswellia frereana (frankincense) suppresses cytokine‐induced matrix metalloproteinase expression and production of pro‐inflammatory molecules in articular cartilage." Phytotherapy Research 24.6 (2010): 905-912.
COLOX™ is beneficial for athletes as it accelerates and supports your body’s natural healing and repair mechanism for injured, inflamed, or strained joints. It reduces pain and inflammation in your joints, with its dual action blocking COX-2 and 5-LOX, making it superior to NSAIDs and other supplements.
Mode of action:
Boswellia serrata and Curcuma longa
- Unived’s COLOX™ is very distinct from NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). NSAIDs blocks either COX-1 or COX-2 pathways and address only the production of prostaglandins, leaving the 5-LOX pathways open for the synthesis of leukotrienes. Furthermore, NSAIDs have no supportive mechanism other than the temporary suppression of pain and inflammation. COLOX™ exerts a dual action in the inflammatory path by blocking both COX-2 and 5-LOX, enzymes that are responsible for the synthesis of prostaglandins and leukotrienes, respectively. Both prostaglandins and leukotrienes are formed when arachidonic acid is released and they play a key role in generating an inflammatory response in the body.
- Boswellia serrata (BS) prevents the degradation of articular cartilage and reduced the degradation of glycosaminoglycans [5] [6].
- BS blocks the overproduction of cytokinetic activity in damaged tissues while enhancing the blood flow to your joints. This eases stiff joints and increases joint mobility. [7]
- Curcuma longa inhibits pro-inflammatory arachidonic acid and neutrophil function during inflammatory states. [8]
- Curcumin increases and prolongs the action of the body’s natural anti-inflammatory adrenal hormone, cortisol, and also improves circulation, thereby flushing toxins out of small joints where cellular wastes and inflammatory compounds are frequently trapped. [9]
Vitamin D3
- Unived’s COLOX™ derives its Vitamin D3 from lichen extracts-the only pure plant-based and vegan source of D3. Vitamin D3 is imperative for bone health, immune function, and inflammatory modulation and it may even be necessary for optimal muscle function and performance
References:
5. Blain, Emma J., Ahmed Y. Ali, and Victor C. Duance. "Boswellia frereana (frankincense) suppresses cytokine‐induced matrix metalloproteinase expression and production of pro‐inflammatory molecules in articular cartilage." Phytotherapy Research 24.6 (2010): 905-912.
6. Siddiqui, M. Z. "Boswellia serrata, a potential antiinflammatory agent: an overview." Indian journal of pharmaceutical sciences 73.3 (2011): 255.
7. Dr. David Jockers, ‘The Super Herb Boswellia – De-inflame and heal’, October 2011, NaturalNew.com
8. Curcuma longa (Turmeric),’Monograph, Alternate Medicine Review, 2001, Volume 6 supplement, pg. S62-S66.
9. Arthritis, NHS Choices, www.nhs.uk
Can COLOX™ be used by vegans?
Yes. COLOX™ can be used by vegans and vegetarians, as it contains purely plant-based ingredients unmixed by any synthetic additives or impurities. It contains no animal products, GMO, soy protein, or wheat gluten.
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SUGGESTED USE
Adults take 2 capsules daily post dinner, with a glass of water.