SUGGESTED USE
Adults take 4 capsules daily post lunch or may opt for 2 capsules post breakfast and 2 capsules post lunch, with a glass of water or as suggested by your Healthcare Professional.
Product Information
Unived’s PCOS Management is formulated to help women who have mild to moderate symptoms of PCOS. It contains clinically proven ingredients Myo-Inositol and D-Chiro-Inositol Inositol in the clinically researched 40:1 ratio (2000mg of Myo-Inositol and 50mg of DCI), which match the body’s ideal physiological ratio the body required in order for a healthy menstrual cycle to function.
The formula also contains key supportive nutrients such as Alpha Lipoic Acid, Chromium Picolinate, Vitamin D3, Folate as L-5-Methyltetrahydrofolate, Calcium from Algae to provide holistic approach to manage PCOS.
We use Caroinostiol® which is a 100% natural D-Chiro Inositol derived from the fruit of the Carob tree, a standardized and studied ingredient that has shown tremendous benefits in cases of PCOS. The product has no fillers or additives.
Key Benefits
- Helps reduce hyperinsulinemia, hyperandrogenism, and leutinizing hormone levels.
- Helps achieve the right hormonal balance.
- Helps regularize menstrual cycle.
- Benefits women with prolonged, stubborn PCOS symptoms.
- Helps reduce symptoms of PCOS like facial hair (hirsutism), acne, and insulin resistance.
- Reduces oxidative stress.
Ingredient Information
- Myo-Inositol – 2000mg
- Alpha Lipoic Acid – 300mg
- Algae calcareas – 206mg
- Caronositol® [Natural D-Chiro-Inositol (97%) from Carob Pods] – 50mg
- Vitashine™ as Cholecalciferol from Lichen – 6mg
- L-5 Methyltetrahydrofolate (95%) – 232mcg
- Chromium Picolinate – 200mcg
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Polycystic ovary syndrome (PCOS) is the most common disorder in women and a major cause of anovulatory infertility. PCOS is a complex heterogeneous disorder that has several aspects in terms of pathology such as metabolic, endocrine, reproductive, and psychological. It is the most common endocrine disease that affect 5 to 10% of women of adolescent and reproductive age.
It is defined and diagnosed by a combination of signs and symptoms of androgen excess, ovarian dysfunction, and polycystic ovarian morphology on ultrasound. There is increasing evidence to suggest that PCOS affects the whole life of women. The causes of PCOS are not fully understood. Several factors such as genetics, diet, lifestyle, underlying neuroendocrine disorders contributes to multiple pathological mechanisms that lead to hormonal imbalance resulting in PCOS.
PCOS happens when there is an increase in levels of androgen, insulin and an increased levels of Luteinizing hormone (LH) and decreased levels of Follicle Stimulating Hormone (FSH). This varying imbalance in the hormones causes the ovaries to produce more testosterone leading to hirsutism, acne, multiple ovarian follicles (cysts), and menstural irregularities because eggs don’t ovulate or ovulate only occasionally.
Key characteristics of PCOS are:
1. Excess production of androgen male hormones. (increase in male type hormones - hyperandrogenism)
2. Increase in insulin resistance. (increased insulin levels - hyperinsulinemia)
3. Increase in Lutenizing hormone (LH) & Follicle Stimulating Hormone (FSH) ratio.
Signs or symptoms of PCOS:
- Irregular periods (more or less often or no periods).
- Polycystic ovaries.
- Absence of ovulation (anovulation).
- Hair growing on the face, stomach, and back (hirsutism).
- Loss of scalp hair.
- Acne.
- Delay in getting pregnant or infertility
- Weight gain or trouble losing weight.
- Depression.
- Risk of developing type 2 diabetes.
Menstural cycle and PCOS:
The menstrual cycle is 24 to 35 days cycle and it refers to the maturing and release of an egg from an ovary and the preparation of the uterus to receive and nurture an embryo. The menstrual cycle is governed by fluctuations in hormone levels in the body, which rise and fall in a monthly pattern. When the cycle is running smoothly, the pituitary gland in the base of the brain produces a hormone called follicle-stimulating hormone (FSH) to prepare an egg for release. The menstrual cycle starts two weeks before your period when the egg is ready and this is when the brain sends signals to release LH and FSH hormones to the ovaries. A large surge of LH stimulates follicles in the ovaries to release an egg (ovulation). While this is happening, the ovaries are secreting other hormones such as estrogen and progesterone to thicken the lining (endometrium) of the uterus and prepare it for pregnancy. The ovaries also produce small amounts of androgens (male hormones), such as testosterone, which is converted into estrogen. If the egg meets the sperm in the fallopian tube, fertilization, and conception may occur. If fertilization does not occur, the endometrium lining sheds and results in menstrual bleeding.
With PCOS, LH levels are often high when the menstrual cycle starts and the levels of LH are also higher than FSH. Because the LH levels are already quite high, there is no LH surge, Without this surge, ovulation does not occur and periods are irregular Women with PCOS may ovulate occasionally or not at all, so periods may be too close together, or more commonly, too far apart. Some women may not get a period at all.
PCOS is not a disease!
PCOS is not a disease that can be cured, it is a syndrome that required supplemental, dietary and lifestyle modification and support. Unived’s PCOS Management plus helps deal with the symptoms to normalize the regular menstrual cycle through the use of inositols.
Unived’s PCOS Management is formulated with clinically proven ingredients to help normalize the menstrual cycle, help reduce hyperinsulinemia, hyperandrogenism, and LH levels, help achieve the right hormonal balance, help reduce symptoms of PCOS like facial hair (hirsutism), acne, and insulin resistance through the use of inositols in a standard ratio and supporting ingredients which reduce the symptoms associated with PCOS.
References:
1. De Leo, V., et al. "Genetic, hormonal and metabolic aspects of PCOS: an update." Reproductive Biology and Endocrinology 14.1 (2016): 1-17.
2. Günalan, Elif, Aylin Yaba, and Bayram Yılmaz. "The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review." Journal of the Turkish German Gynecological Association 19.4 (2018): 220.
3. Carmina, Enrico, and Rogerio A. Lobo. "Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women." The journal of clinical endocrinology & metabolism 84.6 (1999): 1897-1899.
4. Cianci, Antonio, et al. "d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS." Gynecological Endocrinology 31.6 (2015): 483-486.
5. Kalra, Bharti, Sanjay Kalra, and J. B. Sharma. "The inositols and polycystic ovary syndrome." Indian journal of endocrinology and metabolism 20.5 (2016): 720.
6. Genazzani, Alessandro D., et al. "Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome." Gynecological Endocrinology 24.3 (2008): 139-144.
7. Genazzani, Alessandro D., et al. "Modulatory role of D-chiro-inositol and alpha lipoic acid combination on hormonal and metabolic parameters of overweight/obese PCOS patients." Eur Gynecol Obstet 1.1 (2019): 29-33.
8. Fazelian, Siavash, et al. "Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis." Journal of trace elements in medicine and biology 42 (2017): 92-96.
9. dehghani Firouzabadi, Raziah, et al. "Therapeutic effects of calcium & vitamin D supplementation in women with PCOS." Complementary therapies in clinical practice 18.2 (2012): 85-88.
The formula contains Myo-Inositol - 2000mg Caronositol® (Natural D-Chiro-Inositol 97% from Carob Pods)-50mg, Alpha Lipoic Acid-300mg, Algas calcareas-116mg, Vitashine™ Vitamin D3 as Cholecalciferol from Lichen-600I.U., L-5-Methyltetrahydrofolate -220mcg and Chromium Picolinate-200mcg.
Mode of Action:
Two inositol isomers, Myo-Inositol (MI) and D-Chiro-Inositol (DCI) are clinically proven to be effective in PCOS treatment, by improving insulin resistance, serum androgen levels, and many features of the metabolic syndrome.
Under normal physiological conditions, the body maintains a ratio of MI and DCI of 40:1. An enzyme called epimerase is responsible for converting MI-to-DCI, maintaining the physiological ratio of 40:1. The conversion rate of MI-to-DCI becomes less in women with PCOS due to impaired epimerase activity. This results in an imbalanced MI-to-DCI ratio leading to DCI deficiency which promotes insulin resistance in the cells, thereby resulting in metabolic complications.
Maintaining the ratio of 40:1 restores the menstrual cycle, and ovulation, increasing progesterone and decreasing LH, testosterone, and insulin levels. To restore the disturbed inositol balance in women with PCOS Unived’s PCOS Management has formulated with Myo-Inositol and Caroinositol® (DCI) in their physiological ratio of 40:1 along with supporting ingredients. This ensures better clinical results with improved ovarian function & metabolism in PCOS.
Inositols - Myo-Inositol and D-Chiro Inositol along with supporting ingredients plays a part in the process of normalizing one or all hormones that are involved in PCOS and improving the symptoms of PCOS and supporting fertility.
- Myo-Inositol: It is naturally converted to DCI in the body but because of epimerase inactivity the ratio is imbalanced. Thus is important to supplement with both the inositols to achieve balance. MI has shown to lower LH, testosterone and insulin levels significantly, as well as LH/FSH ratio and insulin resistance to some extent.
- Caronositol® - Unived’s PCOS contains natural D-Chiro-Inositol from carob extract which helps with ovulation by maintaining serum progesterone levels, reducing LH/FSH ratio and LH levels also reducing insulin resistance and hyperandrogenism (free testosterone).
- Alpha-Lipoic Acid – is an absolute antioxidant that reduces oxidative stress. It is reported to help with improving ovulation, number of menses, serum progesterone levels, reduction of number of ovarian peripheral cysts. Also helps reduce insulin resistance and insulin levels and increases HDL-C.
- Chromium Picolinate – works as an auto amplification system for insulin signalling and helps reduce fasting blood glucose levels thus aiding the enhancement pf insulin sensitivity. It also helps with reducing testosterone levels.
- Vitamin D3 – is natural and plant-based and helps with reduction of insulin resistance and excessive androgen (male hormone) levels, also helps deal with menstrual dysregulation and improves follicular responses to FSH hormone and normalize AMH levels.
- Calcium – it is very important for regular menstrual cycle as it plays a role in activation of oocytes and improving follicular responses also helps to lower LH levels and increase levels of FSH.
- Zinc – Zinc supplementation has beneficial effect in regulating hormonal balance, glucose metabolism, lipid metabolism, reducing oxidative stress and inflammation.
- Every ingredient plays a part in normalizing one or all hormones that are involved in PCOS. The basic goal is to lower LH, insulin, insulin resistance, androgens, and improve FSH responses. All this together will promote ovulation and regulate menstrual cycles.
What is the suggested use of Unived’s PCOS Management ?
Adults take 4 capsules daily post lunch. One may also opt for 2 capsules post breakfast and 2 capsules post lunch. It is important to ensure you take a 3-6 month course to see clear results. People who have been recently diagnosed and are not seeing severe symptoms may see results faster than someone who has a long history of dealing with PCOS.
What is the difference between PCOS Management Plus and PCOS Management?
PCOS Management Plus is specially formulated for women who have moderate to severe PCOS. If you are diagnosed with hyperandrogenism, irredular or no periods as well as cysts in ovaries – all three conditions, then you have moderate to severe PCOS. PCOS Management is formulated for women who have mild to moderate PCOS. Please refer to our PCOS supplement guide to learn more.
If I take PCOS Management can I stop Metformin?
Metformin is a drug that may have been prescribed to you by your doctor and may have instant results. Our product is a supplement and over time it will make things normalize and the insulin and insulin resistance will go down. We have seen great results with our product within the first month itself, so if you are getting results and your cycle is normalizing, you may not need to consume Metformin. However, if your sugar levels are higher than normal and you have been prescribed metformin for this specific reason, then we advise consulting your doctor before completely stopping metformin.
How long will it take to see results?
It is important to take PCOS Management daily for a period of 3-6 months to make the desired changes. Some individuals will experience results sooner than others as results depend on various factors such as food and exercise as well.
For how long is it safe to use Unived’s PCOS Management?
PCOS is a syndrome that lacks a cure and requires management throughout life. Unived’s PCOS Management can be consumed daily for a period of 6 months, post which we recommend a few week’s break before starting the next consumption cycle.
Along with the product, what else can I do?
We strongly recommend you follow healthy & nutritious food habits and also incorporate exercise into your daily regimen. If you are diligent about both of these, then the product will work quicker and you will experience better results.
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SUGGESTED USE
Adults take 4 capsules daily post lunch or may opt for 2 capsules post breakfast and 2 capsules post lunch, with a glass of water or as suggested by your Healthcare Professional.