FSE.1.2
16-Nov-2023
16-Nov-2024
SUGGESTED USE
Adults take 1 capsule post lunch & 1 capsule post dinner
Product Information
Unived’s Prostate Health is carefully formulated to support and maintain healthy prostate function while addressing common concerns such as frequent urination and night-time urination. As men age, the prostate gland can face challenges such as enlargement, inflammation, and potential health issues, leading to these disruptive urinary symptoms. Our supplement is designed with a unique blend of plant extract & nutrients that are scientifically studied to promote prostate health and alleviate urinary difficulties.
Key Benefits
- Supports prostate health
- Helps promote healthy prostate function
- Helps reduce inflammation
- Helps to reduce urinary discomfort & frequent urination
- Reduce night-time urination and improves sleep quality
Key Benefits
- Pumpkin Seed Extract (Cucurbita pepo Seed Extract) - 500mg
- Beta-Sitosterol (40%) - 323.4mg
- Cranberry Extract (Standardized to 25% Proanthocyanidins) - 250mg
- Lycopene (10%) - 150mg
- Soy Isoflavones (40%) - 100mg
- Zinc Citrate - 56.6mg
- Learn
- Our Formulation
- FAQs
The prostate gland is an important part of the male reproductive system. The prostate gland’s primary function is to produce a fluid that mixes with sperm to form semen. Testosterone plays a crucial role in the development and growth of the prostate gland during puberty. The prostate gland can be susceptible to various conditions and diseases. Some common issues include Prostate Cancer (Pca), Benign Prostatic Hyperplasia (BPH), and Prostatitis (Inflammation of the prostate gland).
Benign Prostatic Hyperplasia (BPH) :
BPH refers to the non-cancerous enlargement of the prostate gland. As men age, the prostate gland can gradually grow larger, leading to compression of the urethra leading to lower urinary tract symptoms (LUTS) such as frequent urination, weak urine flow, difficulty starting and stopping urination, urgency, and weak urine stream. Hormonal imbalances associated with aging and inflammation-induced oxidative stress in the prostate gland contribute to the progression of BPH, making LUTS more common in older men (1).
Dihydrotestosterone (DHT) is a hormone derived from testosterone, and it plays a significant role in the growth and development of the prostate gland. However, excessive levels of DHT can contribute to the enlargement of the prostate gland (2).
DHT is formed when the enzyme 5-alpha-reductase converts testosterone into its more potent form, DHT. In normal circumstances, the balance between testosterone and DHT is maintained. However, as men age, there is an increase in the activity of the enzyme 5-alpha-reductase, leading to higher levels of DHT. This excess DHT can cause the prostate gland to enlarge (2).
Therefore reducing the levels of DHT is one of the strategies used in the management of BPH. DHT blockers, such as medications or natural supplements, work by interfering with the conversion of testosterone to DHT or by arresting DHT from binding to androgen receptors.
There is evidence suggesting that estrogens may play a role in the development of BPH. As men age, their androgen levels decrease, while the conversion of androgen to estrogen increases. Additionally, an age-related increase in body weight and adipose cells leads to higher expression of aromatase, the enzyme responsible for estrogen conversion. The excess estrogens stimulate the growth of prostate tissue, leading to the occurrence of BPH (3).
References:
1. Liu, L. C., Lin, Y. H., Lin, Y. C., Ho, C. T., Hung, C. M., Way, T. D., & Bau, D. T. (2018). Banana Flower Extract Suppresses Benign Prostatic Hyperplasia by Regulating the Inflammatory Response and Inducing G1 Cell-cycle Arrest. In vivo (Athens, Greece), 32(6), 1373–1379.
2. Kinter, K. J., & Anekar, A. A. (2022). Biochemistry, dihydrotestosterone. In StatPearls [Internet]. StatPearls Publishing.
3. Eleazu, C., Eleazu, K., & Kalu, W. (2017). Management of benign prostatic hyperplasia: could dietary polyphenols be an alternative to existing therapies?. Frontiers in pharmacology, 8, 234.
Benign Prostatic Hyperplasia (BPH) :
BPH refers to the non-cancerous enlargement of the prostate gland. As men age, the prostate gland can gradually grow larger, leading to compression of the urethra leading to lower urinary tract symptoms (LUTS) such as frequent urination, weak urine flow, difficulty starting and stopping urination, urgency, and weak urine stream. Hormonal imbalances associated with aging and inflammation-induced oxidative stress in the prostate gland contribute to the progression of BPH, making LUTS more common in older men (1).
Dihydrotestosterone (DHT) is a hormone derived from testosterone, and it plays a significant role in the growth and development of the prostate gland. However, excessive levels of DHT can contribute to the enlargement of the prostate gland (2).
DHT is formed when the enzyme 5-alpha-reductase converts testosterone into its more potent form, DHT. In normal circumstances, the balance between testosterone and DHT is maintained. However, as men age, there is an increase in the activity of the enzyme 5-alpha-reductase, leading to higher levels of DHT. This excess DHT can cause the prostate gland to enlarge (2).
Therefore reducing the levels of DHT is one of the strategies used in the management of BPH. DHT blockers, such as medications or natural supplements, work by interfering with the conversion of testosterone to DHT or by arresting DHT from binding to androgen receptors.
There is evidence suggesting that estrogens may play a role in the development of BPH. As men age, their androgen levels decrease, while the conversion of androgen to estrogen increases. Additionally, an age-related increase in body weight and adipose cells leads to higher expression of aromatase, the enzyme responsible for estrogen conversion. The excess estrogens stimulate the growth of prostate tissue, leading to the occurrence of BPH (3).
References:
1. Liu, L. C., Lin, Y. H., Lin, Y. C., Ho, C. T., Hung, C. M., Way, T. D., & Bau, D. T. (2018). Banana Flower Extract Suppresses Benign Prostatic Hyperplasia by Regulating the Inflammatory Response and Inducing G1 Cell-cycle Arrest. In vivo (Athens, Greece), 32(6), 1373–1379.
2. Kinter, K. J., & Anekar, A. A. (2022). Biochemistry, dihydrotestosterone. In StatPearls [Internet]. StatPearls Publishing.
3. Eleazu, C., Eleazu, K., & Kalu, W. (2017). Management of benign prostatic hyperplasia: could dietary polyphenols be an alternative to existing therapies?. Frontiers in pharmacology, 8, 234.
Unived’s Prostate Health is formulated to target DHT to inhibit excess DHT production or block its activity. They inhibit the 5α-Reductase enzyme to stop the conversion of testosterone to dihydrotestosterone (DHT). It aims to alleviate urinary symptoms and improve overall prostate health. Along with DHT blockers, it also contains ingredients like lycopene and soy isoflavones, which are known for their beneficial effects on prostate health. By incorporating these ingredients, our products aim to provide comprehensive support and management for conditions related to the prostate, such as BPH and UTI.
Role of each ingredient:
Beta-sitosterol: Beta-sitosterol has been found to inhibit the activity of the enzyme 5-alpha reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). It has been studied to reduce BPH symptoms (1, 2).
Pumpkin Seed Extract: Pumpkin seed extract contains phytosterols, including delta-7-sterols, which have been found to effectively inhibit the enzyme 5-alpha reductase which in turn reduces DHT levels. In studies, the extract has been seen to reduce LUTS due to its antiandrogenic activity. It reduces the progression of BPH which ultimately reduces LUTS symptoms (3, 4).
Zinc: Zinc has been shown to inhibit the activity of the enzyme 5-alpha reductase. The concentration of zinc is more in the prostate gland but it declines with age and in the case of BPH. Zinc also has aromatase enzyme inhibition activity. Therefore it helps restrict the conversion of androgens into estrogens (5).
Cranberry Extract – Cranberry extract is been evaluated in reducing LUTS. It may help to relieve the lower urinary tract symptoms typically associated with benign prostatic hyperplasia (BPH), improve International Prostate Symptom Score (IPSS), and reduces the prostate-specific antigen (PSA). It helps to reduce recurrent UTIs in elderly men suffering from BPH (6, 7).
Soy Isoflavones - Due to their phytoestrogenic properties isoflavones, such as genistein and daidzein, can bind to estrogen receptors in the prostate and exert weak estrogen-like effects. They have been studied for their potential to modulate estrogenic activity and inhibit the activity of aromatase which may help to reduce the conversion of androgens to estrogens in the prostate gland. Additionally, soy isoflavones possess anti-inflammatory, antioxidant & 5-alpha reductase inhibition properties, which may further contribute to their potential benefits in managing BPH symptoms (8).
Lycopene – It has an antioxidant and anti-inflammatory properties. Studies speculate that lycopene helps to manage BPH by antioxidant activity, inhibition of cell cycle progression, induction of apoptosis, & increasing gap-junctional cell communication (9).
References:
1. Berges, R. R., Kassen, A., & Senge, T. (2000). Treatment of symptomatic benign prostatic hyperplasia with β‐sitosterol: an 18‐month follow‐up. BJU international, 85(7), 842-846.
2. Klippel, K. F., Hiltl, D. M., Schipp, B., & German BPH‐Phyto study group‡. (1997). A multicentric, placebo‐controlled, double‐blind clinical trial of β‐sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. British Journal of Urology, 80(3), 427-432.
3. Leibbrand, M., Siefer, S., Schön, C., Perrinjaquet-Moccetti, T., Kompek, A., Csernich, A., ... & Kreuter, M. H. (2019). Effects of an oil-free hydroethanolic pumpkin seed extract on symptom frequency and severity in men with benign prostatic hyperplasia: a pilot study in humans. Journal of medicinal food, 22(6), 551-559.
4. Vahlensieck, W., Theurer, C., Pfitzer, E., Patz, B., Banik, N., & Engelmann, U. (2015). Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urologia internationalis, 94(3), 286-295.
5. Sauer, A. K., Vela, H., Vela, G., Stark, P., Barrera-Juarez, E., & Grabrucker, A. M. (2020). Zinc deficiency in men over 50 and its implications in prostate disorders. Frontiers in Oncology, 1293.
6. Vidlar, A., Student, V., Vostalova, J., Fromentin, E., Roller, M., Simanek, V., & Student, V. (2016). Cranberry fruit powder (Flowens™) improves lower urinary tract symptoms in men: a double-blind, randomized, placebo-controlled study. World journal of urology, 34, 419-424.
7. Ledda, A., Belcaro, G., Dugall, M., Feragalli, B., Riva, A., Togni, S., & Giacomelli, L. (2016). Supplementation with high titer cranberry extract (Anthocran®) for the prevention of recurrent urinary tract infections in elderly men suffering from moderate prostatic hyperplasia: a pilot study. Eur Rev Med Pharmacol Sci, 20(24), 5205-5209.
8. Gaynor, M. L. (2003). Isoflavones and the prevention and treatment of prostate disease: is there a role?. Cleveland Clinic Journal of Medicine, 70(3), 203-4.) (Wong, W. C., Wong, E. L., Li, H., You, J. H., Ho, S., Woo, J., & Hui, E. (2012). Isoflavones in treating watchful waiting benign prostate hyperplasia: a double-blinded, randomized controlled trial. The Journal of Alternative and Complementary Medicine, 18(1), 54-60.
9. Sadeghi, A., Saedisomeolia, A., Jalili-Baleh, L., Khoobi, M., Soleimani, M., Fakhr Yasseri, A. M., ... & Nowroozi, M. R. (2022). FruHis significantly increases the anti-benign prostatic hyperplasia effect of lycopene: A double-blinded randomized controlled clinical trial. Frontiers in Nutrition, 9, 1011836.
Role of each ingredient:
Beta-sitosterol: Beta-sitosterol has been found to inhibit the activity of the enzyme 5-alpha reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). It has been studied to reduce BPH symptoms (1, 2).
Pumpkin Seed Extract: Pumpkin seed extract contains phytosterols, including delta-7-sterols, which have been found to effectively inhibit the enzyme 5-alpha reductase which in turn reduces DHT levels. In studies, the extract has been seen to reduce LUTS due to its antiandrogenic activity. It reduces the progression of BPH which ultimately reduces LUTS symptoms (3, 4).
Zinc: Zinc has been shown to inhibit the activity of the enzyme 5-alpha reductase. The concentration of zinc is more in the prostate gland but it declines with age and in the case of BPH. Zinc also has aromatase enzyme inhibition activity. Therefore it helps restrict the conversion of androgens into estrogens (5).
Cranberry Extract – Cranberry extract is been evaluated in reducing LUTS. It may help to relieve the lower urinary tract symptoms typically associated with benign prostatic hyperplasia (BPH), improve International Prostate Symptom Score (IPSS), and reduces the prostate-specific antigen (PSA). It helps to reduce recurrent UTIs in elderly men suffering from BPH (6, 7).
Soy Isoflavones - Due to their phytoestrogenic properties isoflavones, such as genistein and daidzein, can bind to estrogen receptors in the prostate and exert weak estrogen-like effects. They have been studied for their potential to modulate estrogenic activity and inhibit the activity of aromatase which may help to reduce the conversion of androgens to estrogens in the prostate gland. Additionally, soy isoflavones possess anti-inflammatory, antioxidant & 5-alpha reductase inhibition properties, which may further contribute to their potential benefits in managing BPH symptoms (8).
Lycopene – It has an antioxidant and anti-inflammatory properties. Studies speculate that lycopene helps to manage BPH by antioxidant activity, inhibition of cell cycle progression, induction of apoptosis, & increasing gap-junctional cell communication (9).
References:
1. Berges, R. R., Kassen, A., & Senge, T. (2000). Treatment of symptomatic benign prostatic hyperplasia with β‐sitosterol: an 18‐month follow‐up. BJU international, 85(7), 842-846.
2. Klippel, K. F., Hiltl, D. M., Schipp, B., & German BPH‐Phyto study group‡. (1997). A multicentric, placebo‐controlled, double‐blind clinical trial of β‐sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. British Journal of Urology, 80(3), 427-432.
3. Leibbrand, M., Siefer, S., Schön, C., Perrinjaquet-Moccetti, T., Kompek, A., Csernich, A., ... & Kreuter, M. H. (2019). Effects of an oil-free hydroethanolic pumpkin seed extract on symptom frequency and severity in men with benign prostatic hyperplasia: a pilot study in humans. Journal of medicinal food, 22(6), 551-559.
4. Vahlensieck, W., Theurer, C., Pfitzer, E., Patz, B., Banik, N., & Engelmann, U. (2015). Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urologia internationalis, 94(3), 286-295.
5. Sauer, A. K., Vela, H., Vela, G., Stark, P., Barrera-Juarez, E., & Grabrucker, A. M. (2020). Zinc deficiency in men over 50 and its implications in prostate disorders. Frontiers in Oncology, 1293.
6. Vidlar, A., Student, V., Vostalova, J., Fromentin, E., Roller, M., Simanek, V., & Student, V. (2016). Cranberry fruit powder (Flowens™) improves lower urinary tract symptoms in men: a double-blind, randomized, placebo-controlled study. World journal of urology, 34, 419-424.
7. Ledda, A., Belcaro, G., Dugall, M., Feragalli, B., Riva, A., Togni, S., & Giacomelli, L. (2016). Supplementation with high titer cranberry extract (Anthocran®) for the prevention of recurrent urinary tract infections in elderly men suffering from moderate prostatic hyperplasia: a pilot study. Eur Rev Med Pharmacol Sci, 20(24), 5205-5209.
8. Gaynor, M. L. (2003). Isoflavones and the prevention and treatment of prostate disease: is there a role?. Cleveland Clinic Journal of Medicine, 70(3), 203-4.) (Wong, W. C., Wong, E. L., Li, H., You, J. H., Ho, S., Woo, J., & Hui, E. (2012). Isoflavones in treating watchful waiting benign prostate hyperplasia: a double-blinded, randomized controlled trial. The Journal of Alternative and Complementary Medicine, 18(1), 54-60.
9. Sadeghi, A., Saedisomeolia, A., Jalili-Baleh, L., Khoobi, M., Soleimani, M., Fakhr Yasseri, A. M., ... & Nowroozi, M. R. (2022). FruHis significantly increases the anti-benign prostatic hyperplasia effect of lycopene: A double-blinded randomized controlled clinical trial. Frontiers in Nutrition, 9, 1011836.
How long does it take to see results from a prostate health supplement?
The time to see results may vary from person to person. Generally, it is recommended to take a supplement consistently for 3 months to observe results.
Can I take a prostate health supplement if I'm already on medication for my prostate condition?
It is important to consult with a healthcare professional before starting any new supplement, especially if you are currently taking medication for any health condition.
How can I determine if a prostate health supplement is effectively working for me?
The effectiveness of a prostate health supplement can vary from person to person. Here are some indicators that can help you assess if the supplement is working: changes in urinary symptoms such as reduced frequency, improved urine flow, decreased urgency, or reduced nighttime urination. If you notice a positive change in these symptoms, it could indicate that the supplement is having a beneficial effect.
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FSE.1.2
16-Nov-2023
16-Nov-2024
SUGGESTED USE
Adults take 1 capsule post lunch & 1 capsule post dinner